Urinary Fibrinopeptide A in Evaluation of Patients with Suspected Acute Pulmonary Embolism (8)
Currently, V/Q scan is the mainstay in evaluation of patients with suspected PE and frequently is the initial diagnostic procedure that has a major impact on patient treatment. A normal perfusion lung scan virtually excludes PE. On the other hand, the “high probability of PE” V/Q scan in patients with a compatible clinical presentation is accepted widely as sufficient evidence of PE. However, a significant number of patients have equivocal V/Q scan findings and require additional invasive testing. Therefore, a rapid blood or urine test, which could reliably exclude PE, would be very helpful as an initial screening test. Multiple tests have been tried for this purpose, but most were found to be either diagnostically useless or clinically impractical, while others are still debated. A recent comprehensive review of this subject concluded that at the present time, only normal plasma concentration of FPA and fragment E may be helpful in excluding venous thrombosis or thromboembolism. Buy Advair Diskus Online
The FPA concentration reflects the fibrin clot generation rate and, since venous thrombosis is a sine qua non of PE, several investigations have evaluated pFPA as a diagnostic test for PE. In one study, there was a 100 percent sensitivity reported for detection of PE.