Medicine of the Future in America

Urinary Fibrinopeptide A in Evaluation of Patients with Suspected Acute Pulmonary Embolism (10)

Therefore, it is generally agreed that although elevated levels of pFPA or uFPA are not specific for PE, the normal test indicates that the likelihood of PE is very low. ampicillin antibiotic
Although pFPA levels can be useful in excluding PE in suspected patients, the clinical utility of the test has been hampered by the following factors: (1) a blood sample must be carefully obtained by experienced personnel using an atraumatic technique; and (2) the assays available for determination of pFPA were complicated and time-consuming. Recently, an enzyme-linked immunoassay was developed that expedites and simplifies measurement of FPA (Assera-chrom FPA). Another simplification became possible with the demonstration that there was a close correlation of plasma FPA concentration with FPA concentration measurement in a random urine sample. These developments allow convenient and accurate estimation of FPA generation in clinical practice.
We found that a combination of uFPA and V/Q scans ruled out PE in more patients than either test alone (Fig 1). This is not an unexpected finding, since uFPA reflects the rate of fibrin generation and V/Q scans evaluate comparative pulmonary perfusion and ventilation—two functions that are entirely independent. In some patients with pneumonia, the uFPA may be abnormal secondary to the inflammatory reaction while pulmonary perfusion may be either normal or minimally affected.

This entry was posted in Pulmonary function and tagged acute pulmonary embolism, chest roe, fibrin.
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