Medicine of the Future in America

Transient cholestasis in newborn infants with perinatal asphyxia: RESULTS

Of a total of 6737 patients admitted to the neonatology department of Sainte-Justine Hospital between 1989 and 1993, and registered in a neonatology database, 256 (3.8%) were classified as asphyxiated, 659 (9.78%) as small neonates for their gestational age (SGA), and 24 (0.36%) as a combination of both. Of all those registered cases, 212 charts of asphyxiated neonates with appropriate weight for their gestational age (AGA) (90 females), and 22 (12 female) charts of SGA neonates were available for study (after exclusion of one with polycystic kidney disease, one with generalized cytomegalovi-ous infection, and one with urea cycle disease). Of the AGA and SGA cases, 49 (20 female) and four (two female), respectively, died within the first 48 h of life. Thus, data were analyzed from a total of 181 (163 AGA and 18 SGA) asphyxiated infants surviving the first 48 h of their life.

A total of 14 (8.5%, four term and 10 preterm infants) asphyxiated AGA infants and six (33%, one term, five preterm) SGA infants had cholestasis. In both groups, cholestasis developed more frequently in premature newborns. The characteristics of infants with cholestasis are given in more detail in Table 1. Your drugs could be a lot cheaper and your treatment could be still as safe and efficient as always: all you need to do to get your birth control yasmin checkout now is shop at the best pharmacy offering its services to you right here right now.

TABLE 1 Characteristics of asphyxiated appropriate birth weight and growth retarded newborns with cholestasis

Bilirubin (umol/L) Age TPN GA BW Ventilation Glucose
Sex Direct Total (day) (days) (weeks) (grams) Apgar* pH+ (days) (mmol/L) Comorbidity
m 39 156 day 2 none 36 2900 3 2 5 6.9 3 1.1 Myeloproliferative

syndrome

m 52 114 day 4 4-15 41 3410 1 3 4 6.9 10 12.7 Meconium aspiration
m 88 322 day 4 5-12 34 2100 2 6 8 7.0 5 2.3 Muscular VSD, HMD
m 109 250 day 5 none 38 3340 1 3 5 6.8 6 0.2
m 40 246 day 3 5-17 28 1200 4 4 4 7.2 13 3.1 IVH grade 4
m 41 204 day 4 none 28 1250 0 2 7 7.0 5 2.3
m 55 189 day 4 10-29 29 1449 1 1 2 6.7 13 6.7
m 21 81 day 4 7-22 35 1930 1 1 1 7.2 20 1.3
m 26 140 day 3 3-8 24 875 1 4 4 7.2 104 1.9 HMD
m 30 190 day 4 4-41 27 1230 0 4 6 7.2 19 nd
f 27 61 day 2 4-18 41 4135 1 3 3 6.9 21 3.6 Meconium aspiration
f 36 206 day 6 7-87 30 1380 2 4 4 7.2 6 4.0 NEC, IVH grade 3
f 50 233 day 6 5-16 33 1905 1 3 3 nd 2 3.3 Myotonic dystrophy of Steinert
f 30 184 day 5 4-39 25 980 2 3 6 7.2 35 3.2 IVH grade 4
m 28 122 day 3 4-10 36 1920 1 4 5 nd 10 1.7 IVH grade 4
m 48 231 day 6 4-21 37 1365 2 2 4 nd 67 2.5 Pierre Robin syndrome
m 117 269 day 5 8-23 38 1940 1 5 7 7.2 15 2.5 RTN, ASD, BPD
f 35 120 day 4 4-24 29 720 3 6 7 7.0 9 1.8
f 53 165 day 5 3-98 33 1720 1 1 1 7.2 100 1.4 Myotonic dystrophy of Steinert
f 33 185 day 3 5-19 33 1300 0 6 7 7.1 33 3.1 Meconium aspiration

*Apgar 1, 5, and 10 minute value,^First pH measured, umbilical or capillary blood from the neonate. ASD/VSD Atrial or ventricular septum defect; BPD Bronchopulmonal dysplasia; BWBirth weight; f Female; GA Gestational age; HMD Hyaline membrane disease; IVH Intraventricular hemorrhage; m Male; nd No data; NEC Necrotizing enterocolitis; RTN Renal tubular necrosis; TPN Total parenteral nutrition

This entry was posted in Transient cholestasis and tagged Asphyxia, Cholestasis, Newborn.
Copyright © 2012 Medicine of the Future in America www.perfexis.org