Medicine of the Future in America

Transient cholestasis in newborn infants with perinatal asphyxia: METHODS

To select charts for review, a database was used that registered each patient admitted to the neonatology department between 1989 and 1993 as well as definitive diagnoses and complications. Asphyxia was defined by the presence of postanoxic encephalopathy defined by an abnormal Apgar score (a one-minute Apgar score of less than four, a five-minute Apgar score of less than seven, and/or the need for immediate resuscitation or intubation); clinical signs of encephalopathy; and its confirmation by appropriate examinations such as electroencephalogram and brain imaging techniques (echography, computed tomography).

Cholestasis was defined as conjugated bilirubin of more than 18 |imol/L and/or greater than 20% of the total bilirubin concentration. Bilirubin was measured in the clinical biochemistry laboratory at Sainte-Justine Hospital, Montreal, Quebec by automated colorimetric methods (Beckman Synchron CX-5, Beckman Coulter Canada Limited, Missisauga, Ontario). Cholestatic newborns with proven inborn errors of metabolism, infections, malformations and hypothyroidism were excluded from the study.

The results were statistically evaluated by the Mann-Whitney U test for comparision of groups with different sizes and without normal distribution, by the x2 test for comparison of group sizes and by logistic regression for multivariate analysis. Online shopping will cost you less money and will take less time, because you can find efficient birth control for women buy here with generous discounts at the pharmacy that proved its reputability and desire to help by offering best level of service and most efficient drugs.

This entry was posted in Transient cholestasis and tagged Asphyxia, Cholestasis, Newborn.
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