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The Effect of Maximal Doses of Formoterol and Salbutamol from a Metered Dose Inhaler on Pulse Rates, ECG, and Serum Potassium Concentrations (9)

The Effect of Maximal Doses of Formoterol and Salbutamol from a Metered Dose Inhaler on Pulse Rates, ECG, and Serum Potassium Concentrations (9)On the selection day, abnormalities in the ECG recordings were seen three times: two patients had a left axis deviation and one had left ventricular hypertrophy. The other ECGs were all normal.
Before the start of the study, 11 patients had used inhaled 02 mimetics and one had taken oral ($2~ mimetics. One patient took xanthines, and two inhaled ipratropium bromide. One patient was receiving cro-moglycate. There were eight patients who took inhaled steroids and four patients in whom these drugs were given orally. One patient with diabetes mellitus was taking tolbutamide. One additional patient was also receiving cimetidine in connection with stomach problems.
The maximal dosage of formoterol that was given by inhalation was 228 jig in one patient, 180 |xg in three patients, 132 \ig in three patients, and 84 jjig in six patients. The corresponding figures for salbutamol were 3,800 in one patient, 3,000 jig in one patient, 2,200 |xg in eight patients, and 1,400 jig in three patients. Table 1 gives a general view of the number of puffs used and describes the motivation for not going on further with successively higher doses.

Table 1—Total Number of Puffs Administered

Total No. of Puffs Formoterol Salbutamol
No. Patient fig No. Patient
2 12 200
6 36 600
14 84 6 2, 3, 4, 1,400 3 3, 12, 13
7, 11, 13
22 132 3 1, 8, 10 2,200 8 1, 2, 4, 6,
7, 8, 10, 11
30 180 3 6, 9, 12 3,000 1 9
38 228 1 5 3,800 1 5
Reason for Premature Discontinuation
Formoterol Salbutamol
Reason No. Patient No. Patient
1. No increase in FEV, 10 1, 3, 4, 11 1,3, 4, 6,
above 5 percent 6, 7, 8, 7, 8, 9, 10,
9, 10, 11, 13 11, 12, 13
2. Abnormal ECG 1 2 1 2
3. 2 and decreasing 1 12
subjective well
being
This entry was posted in Pulmonary function and tagged arrhythmia, bronchospasmolytic effect, salbutamol.
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