The pulse rates were measured by a pulse oximeter and ECG tracings were registered by a 12-channel ECG (Electronics MAC PC 005). A careful watch was kept for unwanted drug effects.
As statistical method, the analysis of variance test was employed using the baseline parameter (recorded before administration of the first dose of trial medication) as covariate. All tests were carried out with a two-sided alpha of 0.05. The values recorded after the last puff for the individual patient were used as the “last values.”
Thirteen patients consented to participate in the study. There were 12 men and 1 woman with an average age of 47.2 years, height of 174.5 cm, and body weight of 83.6 kg. They had suffered from bronchial asthma for a mean period of 22.3 years. buy cheap antibiotics
The mean pulse rate was 73*min~ l> the mean systolic blood pressure was 124 mm Hg, and the diastolic blood pressure was 83 mm Hg. The mean basal FEV! was 1.88 L (50 percent of the reference value) that increased, on average, after 200 \ig of salbutamol by 27 percent to 2.37 L. The mean serum potassium concentration on the day of selection was 4.48 mmol*L_1 and all the results on this day were within the normal reference values (3.5 to 5.0 mmol*L_l).