All study patients had been taught the MDI inhalation technique and their ability to do this correcdy was specifically checked on the selection day. The measurements were repeated 1 hour later and the second dose of 4 puffs was given immediately thereafter. Measurements, followed by administration of the next dose, were then repeated every hour until it appeared that the maximal dose had been reached. If that point had not yet been reached, the patient was given lunch (which was standardized as to the potassium content) and the study continued further. Before the second study day, at least 48 hours after the start of the first one, the patient returned for the second day.
The lung function tests were carried out in duplicate and the best values (BTPS corrected) were retained. A specific pulmograph (from the firm Sensor Medics) was employed. The following parameters were noted: forced expiratory flow in 1 s (FEV, in liters); forced vital capacity (FVC in liters); mean forced expiratory flow during the middle half of the FVC (FEF25-75%) in L/s; and peak expiratory flow (PEF) in L/s. birth control yasmin
Serum potassium levels were measured by a flame emission photometer (Instrumentation Laboratory 943) from 10-ml venous blood samples via a cannula in the antecubital vein.