Oral corticosteroids were allowed only if taken in constant dosage and (3-blockers or other cardiac drugs were forbidden. The inhalation of cromoglycate or inhaled steroids was allowed in principle, provided the drugs were taken in a constant dosage throughout the entire study period. Smoking and consumption of caffeine-containing drinks were not allowed on the measurement days. The study was approved by the Medical Ethical Committee of the institute and all patients gave witnessed informed consent to participation. Buy Advair Diskus Online
Every patient who satisfied the admission criteria was treated for two days with either formoterol or salbutamol from a metered pressure aerosol (MDI), with a period of at least one whole day (generally approximately 36 hours) between the two active treatment days. To keep the influence of the weather, the season, and the barometric pressure to a minimum, the 13 selected patients were all tested between August 7, 1989 and September 7, 1989, at a rate of three patients per week. The order of treatment was randomized into blocks of four patients with the treatment sequences A-B or BA, A consisting of two 6-|xg puffs of formoterol and B consisting of two 100-jig puffs of salbutamol. The MDIs for the two drugs were identical in appearance. Doses were given at intervals of 1 hour.