Finally, we believe that there are several practical conclusions to be drawn for possible future trials with high doses of fVnumetics when an investigation into tolerability is the main aim. proventil inhaler
In the first instance, one might think that it would be worthwhile for all patients to receive the planned cumulative doses in their totality to produce a single homogeneous patient group and thus avoid some subsequent statistical problems. These could be awkward if there was a patient group that tended to receive higher equivalent dosages with one regimen than with the other. However, it is quite possible that this approach might lead to problems in patients who required only a lower dose of p2’mime^c to score a maximal bronchospasmolytic effect. In addition, it would seem sensible to us to continue the investigation for 4 to 6 hours after the last dose of any p2-mimetic agent, especially to study the latter patterns of the serum potassium concentrations. And, finally, it would seem useful to carry out Holter monitoring during the whole study period to be more completely informed about the development of any cardiac arrhythmias.