In general, the patients finished the trial one dose earlier after formoterol than after salbutamol, but we believe that each individual patient can be said to have his own maximal dose of p-mimetics. We might suggest rather speculatively that every asthma patient has a certain number of p-receptors and, therefore, that a specific individual dose of p-mimetics is necessary to cover them. antibiotics levaquin
Most patients in the study reached the peak effect after the third (six formoterol, three salbutamol) or fourth dosage rounds (three formoterol and salbutamol), ie, after the inhalation of 84 or 132 |Ag of formoterol and 1,400 or 2,200 |ig of salbutamol. The mean maximum increase in FEV, was 36 percent after formoterol and 35.1 percent after salbutamol. The mean increase after 200 |xg of salbutamol on the selection day was 27.2 percent. From this it might be concluded that the maximal bronchospasmolytic effect (expressed as the maximal increase over the basal FEV, on both the treatment days) was comparable for equivalent dosages of formoterol and salbutamol. One might suggest further that cumulative doses higher than 132 |xg of formoterol (and in many cases even much lower doses) failed to produce any further improvement in lung function and were thus not necessary.