Medicine of the Future in America

Skin metastasis from an occult esophageal adenocarcinoma: CASE PRESENTATION (Part 2)

Axial spiral computed tomography scan of the abdomen with contrast revealed thickening in the fundus of the stomach with extension to the cardia, with no peripheral lymphadenopathy. A biopsy of the distal esophagus revealed the characteristic histological features of adenocarcinoma (Figure 3), and an esophageal extension of a gastric carcinoma remained to be excluded. Additional work-up at that time showed no evidence of extracutaneous metastasis. The patient was unique in that she had skin metastasis for one month as the initial manifestation of a primary esophageal adenocarcinoma in the absence of any local symptoms. The patient was given chemotherapy. After six months of chemotherapy there was no change in the size of the tumour and rebiopsy revealed the same histopathology as the initial specimen. Your online shopping for cialis professional is going to be as advantageous as never before.
Histopathological features
Biopsy of the facial skin revealed unremarkable epidermis and involvement of the dermis by an epithelial tumour showing glandular structure with moderate cellular pleomorphism (Figure 1). Biopsy of the esophageal mucosa showed a similar epithelial-type tumour, with occasional glandular structures and composed of cells with eccentric, hyperchromatic nuclei (Figure 3). Figure_3Figure 3) Adenocarcinoma in the esophageal mucosa identical to that in the dermal infiltration. Hematoxylin and eosin staining, original magnification x200

This entry was posted in Skin metastasis and tagged Cutaneous metastases, Esophageal adenocarcinoma, Histology, Oncology, Pathology.
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