Medicine of the Future in America

Respiratory Symptoms and Lung Function in Animal Feed Workers: Pulmonary Function—Present Exposure

Respiratory Symptoms and Lung Function in Animal Feed Workers: Pulmonary Function—Present ExposureSymptoms (cough, phleghm, chronic bronchitis, breathlessness, wheezing, asthmatic attacks) were included if a subject had positively responded to a question in a category. Three separate logistic regression analyses were performed with the respiratory symptom as the dependent variable and the confounders (age, height, pack-years) and spirometric or impedance or exposure parameters as the independent variables. Exposure was not regarded as a confounder in this relationship.
Subjects using inhalation drugs (four in the exposed group only) were excluded from statistical analyses since this may lead to an underestimation of respiratory resistance. All procedures, if not stated otherwise, were computed with the mainframe software package (SPSS-X, SPSS-X Inc, 111). allergy relief

In these facilities, 54 measurements of dust and endotoxin exposure were gathered. For the seven job titles in the production group (maintenance personnel were excluded), mean exposures to inspirable dust and endotoxin are given in Table 2. Regression analysis revealed that average dust and endotoxin exposure differed significantly among different job titles (p<0.01). Highest exposures were met with in unloaders, press operators, and “jacks of all trades/’.
Mean pulmonary function values of controls and exposed workers are listed in Table 1. On average, exposed are older, shorter, have smoked more pack-years, and have similar weight compared with controls. All flow volume parameters, FD and X8 are decreased, whereas RS and fo are increased in exposed compared with control workers. These findings indicate an increase in airflow obstruction in the exposed group. Mean FEVi and FEF parameters decreased significantly with increasing exposure by category adjusted for age, height, and smoking (Table 3).

Table 3—Mean Values of Lung Function in Control Workers and Production Workers Classified Into Exposure Categories, With Respect to Airborne Dust

Lung Function Parameter Controlsn=54 0-4 mg/m* n=97 4-9 mg/m* n=17 > 9 mg/m* n=25
FVC, L 5.63 (0.12) 5.34 (0.08) 5.37 (0.20) 5.28 (0.21)
FEVb L 4.51 (0.11) 4.20 (0.08)f 4.10 (0.08) f 3.99 (0.20)§
PEF, L/s 12.34 (0.24) 11.46 (0.18)f 10.69 (0.35)| 10.35 (0.32)§
MMEF, L/s 4.45 (0.21) 3.80 (0.13)| 3.52 (0.40)| 3.30 (0.29)§
MMEF75, L/s 9.54 (0.34) 8.74 (0.22)| 8.03 (0.61)| 7.38 (0.49)§
R8, hPa.s/L 2.23 (0.09) 2.52 (0.09)| 2.54 (0.28)| 3.50 (0.34)§
X8, hPa.s/L -0.03 (0.03) -0.08 (0.04)| -0.24 (0.17)| -0.50 (0.16)§
FD, hPa.s/L 0.29 (0.04) 0.16 (0.06)f 0.07 (0.13)| -0.43 (0.20)§
f0, Hz 8.46 (0.20) 9.21 (0.35)f 10.88 (1.47)| 14.11 (1.48)5
This entry was posted in Pulmonary function and tagged airflow obstruction, early diagnosis, endotoxin, flow volume curves, forced-oscillation technique, inspira-ble dust, occupational.
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