The patients in this study have been characterized with respect to lung volumes and lung mechanics at rest by recording the complete static PstL/V curve and by measuring lung resistance by the interrupted constant flow method. Static lung compliance was on average reduced, and more often pathologic than lung volumes. A common finding was also a substantial increase of Rl. We now report measurements of lung mechanics and gas exchange at rest and exercise at the breathing pattern spontaneously chosen by the patient, which were obtained on the same occasion. antibiotic levaquin
Dynamic lung compliance and functional lung resistance were thus measured at rest and at maximal exercise. The CdynL at work was reduced almost to the same extent as CstL even in the subgroups. At maximal exercise, CdynL is measured at a high breathing frequency and might be expected to be influenced by airway resistance. We found no correlation between CdynL at maximal work and lung resistance, indicating that CdynL even at a fairly high breathing frequency mainly reflects parenchymal disease. Measurements of CdynL at maximal exercise resulted in a greater number of abnormal observations than CdynL at rest and as many abnormal observations as CstL. The CdynL at exercise has not previously been studied in sarcoidosis.