Medicine of the Future in America

Lung Mechanics and Gas Exchange During Exercise in Pulmonary Sarcoidosis (10)

The CdynL at exercise correlated closer to VC than to TLC (r = 0.69, p<0.001, and r=0.46, p<0.001, respectively). A multiple orthogonal regression analysis between CdynL at work (dependent variable) and CstL and Rl (independent variables) showed no significant influence of Rl on CdynL. Twenty-eight subjects had abnormally low CydnL at maximal work but only ten of these showed abnormally low CdynL at rest. Of the 28 subjects with low CdynL at maximal work, 27 had pathologic findings in their lung volumes or static PstL/V curves at rest (Fig 3). buy cheap antibiotics
The RfL at maximal work correlated significantly to Rl and to RfL at rest (in both cases r = 0.77, p<0.001). A somewhat looser relationship was seen between RfL at rest and Rl (r = 0.56, p<0.001). The RfL at work also correlated significantly to VC (r= —0.50, p<0.001), RV (r = 0.39, p<0.01), FEV, (r=-0.75, p<0.001), and FEV,%VC, (r= -0.78, p<0.001). Twenty-one patients had abnormally high RfL at work, while RfL at rest revealed high resistance in 10 of the 21 subjects. Abnormal values of FEV,%VC, RX and/ or Rl were seen in 18 of the 21 subjects with high RfL at work (Fig 4).

Figure-3

Figure 3. CdynL at maximal work was abnormal in 28 patients. Shown in the figure are the number of these subjects who had abnormal values of VC, TLC and/or abnormal static PstL/V-curve with reduced slope. One patient had normal VC, TLC and PstL/V-curve but low CdynL.

Figure-4

Figure 4. RfL at maximal work was abnormal in 21 patients. Displayed are the number of the patients with low values of FEVj% VC, high values of RY and/or high Rl. Three patients with high Rfi. had normal FEV,%VC, RY and Rl.

This entry was posted in Pulmonary function and tagged gas exchange, lung function, sarcoidosis.
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