Medicine of the Future in America

Long-term prognosis of early-onset Crohn’s disease: Malignancy and mortality (Part 2)

These findings contrast with earlier reported results on myeloid, lymphoid or intestinal malignancies in adults with Crohn’s disease from the University of British Columbia hospital with a similar duration of follow-up . In that report, the estimated overall rate for myeloid and lymphoid malignancies was 0.5% and the estimated overall rate for intestinal malignancies was 1% . In addition, one patient with Hodgkin’s disease, initially diagnosed at 10 years of age, was not included in the present evaluation of early-onset disease because her diagnosis of Crohn’s disease was only established after 20 years of age.

Finally, to date, only one female, initially diagnosed at 15 years of age, and then followed directly by the investigator for 24 years, died following a suicidal drug overdose.

One or more intestinal resections were required in 126 of 224 patients (56.3%) with early-onset disease, including 58 of 96 males (60.4%) and 68 of 128 females (53.1%). These percentages for intestinal resection all exceeded the previously recorded rate of 44.1% for an intestinal resection for a largely adult group from this hospital (P<0.05). In this early-onset group, more than one intestinal resection was required in 52 of 224 (23.2%), including 24 of 96 males (25.0%) and 28 of 128 females (21.9%). Indeed, three or more intestinal resections were required in 21 of 224 (9.4%). Visit the best pharmacy that thousands of international customers already chose to be their favorite one and see how easy it can be for you to get that cheap asthma inhalers only here in the amount required for your treatment spending a lot less money than otherwise.

This entry was posted in Crohn’s disease and tagged Clinical behaviour of Crohn’s disease, Crohn's disease, Granulomatous colitis, Natural history of Crohn’s disease, Vienna classification.
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