Medicine of the Future in America

Long-term prognosis of early-onset Crohn’s disease: Malignancy and mortality (Part 1)

intestinal malignancyOnly a single male with early-onset disease among these 224 patients developed an intestinal malignancy. He was initially diagnosed with Crohn’s disease at 17 years of age in 1977. Endoscopic and radiological studies defined ileocolonic involvement. He was subsequently treated with different 5-aminosalicylate preparations, including sulfasalazine and eventually metronidazole, but no corticosteroids or immunosuppressive agents. He required an ileocolonic resection in 1980 for a localized ileal perforation proximal to a strictured ileal segment. Ileal and colonic ulcerations were present but granulomas were not detected in the resected intestine. Later, three colonoscopies with multiple ileal and colonic biopsies over the course of two decades showed only patchy inflammatory mucosal changes without granulomas. No dysplasia was detected. In 2003, he developed an anorectal stricture due to a low lying rectal adenocarcinoma and required an abdominoperineal resection.

To date, no patient with early-onset Crohn’s disease has developed a myeloid or lymphoid malignancy, and all colonoscopic biopsies, either from macroscopically normal or abnormal intestine, have not demonstrated dysplasia. In addition, dysplasia has not been reported in resected intestine. Shop online with the best pharmacy that will ensure high quality of your medications and will offer cheapest cheap asthma medications here with no rx required any time you need this or any other one for your medical problem.

This entry was posted in Crohn’s disease and tagged Clinical behaviour of Crohn’s disease, Crohn's disease, Granulomatous colitis, Natural history of Crohn’s disease, Vienna classification.
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