Medicine of the Future in America

Long-term prognosis of early-onset Crohn’s disease: DISCUSSION (Part 3)

The data here indicate that an intestinal resection, if required, will usually be performed within two years of the initial diagnosis. Moreover, if a second resection is required, this is also frequently done within two years following the first resection. While it was not possible to evaluate the effects of therapy on the natural history of Crohn’s disease before resection in the present study, future investigations focused on new therapeutic drugs and biological agents should distinguish early-onset from adult onset disease.

The present study in early-onset Crohn’s disease also explored the effects of disease location and clinical behaviour on rates of intestinal resection. In this investigation, disease located in the ileocolonic region and characterized as complex disease with intestinal strictures or, more frequently, penetrating (or perforating) disease complications were independent risk factors that often predicted a later intestinal resection. These observations confirm the clinical experience that children or adolescents with Crohn’s disease are more likely to require surgical treatment relatively soon after diagnosis if disease is clinically complicated with stricture formation or penetrating disease complications, such as the development of an abscess or a fistulous tract. Further studies are needed to define other prognostic factors that might predict the need for earlier surgical treatment of Crohn’s disease. You need to treat your health condition as soon as possible? Nothing is impossible anymore, because you have the best canadian neighbor pharmacy at your service, offering finest quality medications with full guarantee of your satisfaction.

This entry was posted in Crohn’s disease and tagged Clinical behaviour of Crohn’s disease, Crohn's disease, Granulomatous colitis, Natural history of Crohn’s disease, Vienna classification.
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