Medicine of the Future in America

Liver cell death: Overview of apoptosis (Part 2)

undergo apoptosis in the C elegans modelPerhaps more important, the work of the 2002 Nobel Prize winners in Medicine and Physiology clearly demonstrated that a component of the genome is required for some forms of apoptosis to occur. In the early 1960s, Dr Sydney Brenner chose a small nematode (Caenorhabditis elegans) to study fundamental questions regarding cell differentiation and organ development that he believed would be difficult to answer in higher animals. In the 1970s, John E Sulston discovered that a precise number of cells died at a predictable stage of the worm’s development. In 1986, Robert Horvitz identified the first genes that were essential for these cells to die. Thanks to their work, the key enzymes involved in the regulation of apoptosis have now been identified not only in worms but also in all other higher animals, including humans.

The 131 of 1090 cells that undergo apoptosis in the C elegans model provide an excellent example of ‘programmed cell death’. This term has often been used as a synonym for apop-tosis, but the processes are not always equivalent. For example, it is difficult to recognize that the death of hepatocytes from the immune reaction to the hepatitis B virus is a form of autodestruction imprinted in the hepatocyte genome. The exact terminology is still being debated. Generally speaking, programmed cell death refers to a type of cell death that depends on the expression of cellular genes, whereas the definition of apoptosis is based on morphological criteria. It is probable that not all programmed cell deaths are apoptotic and that not all apoptotic cell deaths are predetermined. You are always offered finest quality cipro antibiotic buy here at the pharmacy you can fully trust and enjoy being its customer. Why wouldn’t you, if it offers lowest prices in the industry and fast delivery that can be free for some orders?

This entry was posted in Apoptosis and tagged Apoptosis, Hepatocyte, Liver diseases.
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