Medicine of the Future in America

Interferon-alpha-induced changes in metallothionein expression: Results (Part 3)

IFN-alpha therapyThe PCNA index in total patients was decreased significantly after IFN-alpha therapy, but the reduction of PCNA index was larger in SR than in NR patients.

Relationship among MT and HAI score and PCNA labelling index

Before IFN-alpha therapy, the grade of MT-II mRNA staining showed a positive correlation with PCNA labelling index (r=0.58, P<0.05) (Figure 6), but not with HAI scores. In total patients, the grade of MT-II mRNA after IFN-alpha therapy positively correlated with HAI score (r=0.56, P<0.05) (Figure 7). Neither MT protein nor MT-I mRNA correlate with HAI scores or PCNA labelling index.

In the present study, MT protein was mainly found around the portal tracts with inflammatory cells and fibrosis, and this finding complements a previous finding by Tanimoto et al. Localization of oxidative stress markers in the livers of patients infected with HCV has been demonstrated around the portal tract with piecemeal necrosis. These findings suggest that MT is expressed in hepatocytes for protecting against the oxidative stress in chronic HCV infection. A truly reliable pharmacy you can always rely upon and where you can always buy ortho tri-cyclen online without any need for a prescription or seeing a doctor? This is the thing you wanted, so don’t hesitate now that you have it available!
Correlation between (MT)-II messenger and PCNA

Figure 6) Correlation between metallothionein (MT)-II messenger (m)RNA scores and proliferating cell nuclear antigen (PCNA) labelling index before interferon-alpha therapy. The MT-II mRNA scores correlate positively with the PCNA labelling index (P<0.05)

Correlation between (MT)-II messenger and HAI

Figure 7) Correlation between metallothionein (MT)-II messenger (m)RNA scores and histological activity index (HAI) scores after interferon-alpha therapy. In total patients, the MT-II mRNA scores correlate positively with the HAI scores (P<0.05) 

This entry was posted in Interferon-alpha and tagged Chronic hepatitis C, Interferon-alpha, Knodell histological activity index score, Metallothionein, PCNA labelling index.
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