Medicine of the Future in America

Interferon-alpha-induced changes in metallothionein expression: Discussion (Part 2)

HCV patientsZinc is considered to exert a protective action on liver cell activity and to prevent damage caused by oxidative stress through induction of MT. MT gene expression and protein synthesis are induced by IFN during normal or adequate zinc status, but not during periods of zinc deficiency. As was observed in our previous study, serum zinc levels were decreased in NR patients after completion of IFN therapy, consequently diminishing MT protein in the liver. In addition, the induction of the hepatic MT gene by IFN is so rapid and transient that the occasionally performed liver biopsy probably influences MT levels. In the present study, the liver samples taken one year following completion of IFN-alpha therapy were evaluated, which might have caused difficulty in defining the precise induction of MT by IFN-alpha. Additional studies using liver samples taken during IFN-alpha therapy are needed to fully assess MT induction by IFN-alpha and its potential for providing a beneficial role for HCV patients. Your turn to find out more about the possibility to get cheap ventolin inhalers and pay tons less.

MT-I and MT-II genes are actively expressed in many cell types in different organs and tissue, as well as in most cultured cells. The MT-II isoform is the predominant form in human tissue, but the relative proportion of the isoproteins depends on the particular stimulus.

This entry was posted in Interferon-alpha and tagged Chronic hepatitis C, Interferon-alpha, Knodell histological activity index score, Metallothionein, PCNA labelling index.
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