Six patients (five female, one male) with respiratory failure consequent upon restrictive ventilatory disease consented to the study. Four patients had idiopathic thoracic restrictive disease (kyphoscoliosis), one patient had postpolio kyphoscoliosis, and one patient had neuromuscular disease associated with a peripheral neuropathy of undetermined origin. All patients had required acute ventilatory support on one or more previous occasions. They had received close clinical supervision for a number of mQnths during which time there had been no spontaneous improvement in their respiratory condition. buy cipro
Although their nocturnal desaturation could be corrected by administering supplemental oxygen, this had resulted in unacceptably high levels of Pco2 necessitating mechanical ventilatory support. The patients were highly motivated to return to full-time employment and had been referred for respiratory rehabilitation. After initiation of elective ventilation, patients participated in a supervised in-patient multidisciplinary exercise rehabilitation program. This six-week program consisted of twice-daily exercises on a treadmill or individually supervised interval training for five days each week. The program included upper limb endurance training, educational and relaxation classes, but it did not include inspiratory muscle endurance training.