Medicine of the Future in America

Inflammatory bowel disease research: THE CCFC IBD RESEARCH NETWORK (Part 2)

The second study initiated by the Network aimed at establishing a national registry of IBD patients in Canada. This project was prompted not only by the obvious need for data on the incidence and prevalence of IBD in Canada, but also by the work of Dr Charles Bernstein and coworkers who used data from the Canadian province of Manitoba’s single health insurer (Manitoba Health) to determine the incidence and prevalence of IBD.

This database has subsequently been used to calculate direct costs, cancer risk and drug use of IBD patients in that province. A team consisting of Dr Bernstein (Manitoba), Dr Sutherland (Alberta) and Dr Irvine (Ontario) has been assembled to determine the extent to which administrative health data can be used in other Canadian provinces to determine the incidence and prevalence of IBD in Canada. The preliminary work from Ontario wasjust published by Dr Irvine’s group, demonstrating the utility of this method in other provinces.

The third Network project, prompted by the Foundation’s challenge of finding the cause(s) of IBD, addressed the question of a microbial etiology of these disorders. Under the guidance of the CCFC Network Committee member Dr Philip Sherman, several experts in enteric microbiology were invited to attend a think tank in January, 1999 to discuss the feasibility of examining a microbial etiology of IBD. The Network committee was persuaded that such an examination was indeed feasible given the developments in the molecular identification of microbes, and in 2001 announced a request for research applications (RFA). An international panel of experts evaluated the submissions and two projects were selected for support. You can enjoy cheap drugs that work – cialis professional to benefit the most from it.

One is from Dr Gerald Tannock at the University of Alberta in Edmonton. Dr Tannock will examine mucosa-associated flora from inflamed and noninflamed regions of the ileum and colon of newly diagnosed but untreated patients with Crohn’s disease and ulcerative colitis. Dr Ernest Seidman and his collaborators from the University of Montreal in Quebec will examine tissue from IBD patients for evidence of infection with cytomegalovirus, measles and parmyxovi ruses, Mycobacterium avium intracellulare, as well as Campylobacter and Helicobacter species.


This entry was posted in Inflammatory bowel disease research and tagged Crohn's disease, Database, Epidemiology, Genetics, Microbes, Ulcerative colitis.
Copyright © 2012 Medicine of the Future in America