Medicine of the Future in America

Exudative Polyserositis and Acute Respiratory Failure Following Praziquantel Therapy: Discussion (1)

In our opinion, this patient’s stormy illness was the result of administration of praziquantel for the following reasons: (1) the reaction started w ithin four hours of administration of praziquantel; (2) marked eosinophilia which improved spontaneously; (3) other conditions w ere excluded that might have caused his illness, for example, disseminated pyogenic or tuberculous infection, metastatic disease, or collagen vascular disorders; (4) rapid and complete resolution occurred without the help of any specific medication; (5) all the manifestations of his illness with the exception of polyserositis were described previously as side effects of therapy w ith praziquantel or other antisehistosomal drugs.
Praziquantel is recommended as a drug of choice in all forms of schistosomiasis and it is generally well tolerated with only minor side effects such as abdominal pain, headache, dizziness, epigastric discomfort, bloody diarrhea, or mild fever. buy antibiotics online
Our patient developed acute respiratory failure that preceded the appearance of any significant pleural effusion in a manner denoting ventilation-perfusion mismatch. Interestingly, similar reactions were described following administration of other antisehistosomal drugs but not praziquantel.

This entry was posted in Pulmonary function and tagged antisehistosomal drugs, biopsy specimen, diarrhea, respiratory failure, schistosomiasis.
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