Medicine of the Future in America

Exudative Polyserositis and Acute Respiratory Failure Following Praziquantel Therapy (1)

Exudative Polyserositis and Acute Respiratory Failure Following Praziquantel Therapy (1)Praziquantel, a mixture of stereoisomers of pyrazinoiso-quinoline ring structures, is a broad-spectrum antihelminthic that is effective against all forms of human schistosomiasis. It is generally well tolerated with only minor side effects, such as abdominal pain, headache, dizziness, epigastric discomfort, bloody diarrhea, or mild fever. ’ We report an unusual complication of praziquantel therapy in schistosomiasis. Although some of the manifestations of our patients illness, such as fever, skin rash, and diarrhea, have been described in acute schistosomiasis, this patient had hepatosplenomegalv and periportal fibrosis that persisted after recovery from acute illness making the possibility of chronic schistosomiasis more likely. buy asthma inhaler
Case Report
A 21-year-old man presented to another hospital with abdominal pain and bloody stools. Stool microscopy showed Schistosoma nutnsoni ova hut examination for other parasites was negative*. He was given 1.8 g of praziquantel as a single dose. Within four hours of taking this medication, he developed a generalized papulomaciilar itchy rash that was accompanied by myalgia, fever, abdominal pain, diarrhea, and severe pleuritic chest pain. He presented to King Khalicl University Hospital 48 h later as the symptoms grew worst*.

This entry was posted in Pulmonary function and tagged antisehistosomal drugs, biopsy specimen, diarrhea, respiratory failure, schistosomiasis.
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