The 6-min walk test was performed in accordance with the American Thoracic Society guidelines.
Upper- and Lower-Extremity Maximal Strength Testing
Subjects were shown the correct technique required to perform eight (chest press, shoulder press, vertical row, triceps extension, biceps curl, latissimus dorsi pull down, leg extension, and leg curl) strength exercises, after which time they were given an opportunity to perform each exercise. The heaviest weight lifted once while adhering to strict technique was used as the one-repetition maximum (1RM). The 1RM test was repeated a second time within a 1-week period, and the highest score of the 2 days was used as the baseline score.
Health-related QOL was assessed using the MacNew heart disease health-related QOL instrument, which measures the physical, emotional, social, and global domains of well-being. starlix 60 mg
Randomization and Interventions
After the baseline testing, subjects were randomly assigned to 8 weeks of AT or COMT. AT was performed 3 d/wk at 70 to 85% of peak heart rate for 30 min per session using treadmill or cycle ergometers. The COMT subjects performed the same aerobic program as the AT subjects. They also performed one to two sets of 8 to 10 repetitions of the previously described strength-training exercises. The initial intensity was set at 55% of 1RM, and increased by 2.5% every week.
Statistical analysis was performed with a two-way, repeated-measures analysis of variance. If a significant effect was found, then a Neuman-Kuels post hoc test was performed. The a level was set a priori at p < 0.05. Data are presented as mean ± SD.
Three subjects did not complete the investigation. One AT subject completed < 80% of the required exercise sessions, while another AT subject dropped out of the study due to worsening of asthma not related to participating in the study. One COMT subject dropped out of the study due to family reasons. Thus, nine AT subjects (mean age, 70 ± 6 years) and nine COMT subjects (mean age, 71 ± 7 years) completed the study, with adherence rates of 96% and 98%, respectivelyю