To discontinue the drug at the end of the study period, the infusion was tapered off over a 2-h period. buy cipro
Pnospectively Randomized Dials: Fluid volume was routinely given until either the optimal therapeutic goals were achieved or PaOP greater than 15 mm Hg was reached. If optimal goals were not achieved by the time PaOP reached 15 mm Hg, the patient was considered eligible for this study. After informed consent was obtained, a card was removed from a numbered sealed opaque envelope, previously prepared by an outside person from a random number table. This card determined if the patient would receive PGE, or a placebo. The PGE, or placebo was given as described previously for the open-label trials; the physicians responsible for patient care and making measurements were blinded to the agent being given.
We evaluated the hemodynamic and oxygen transport values obtained in the control period and values at each dose levels and 2 h after the 60 ng/kg*min or highest dose used by an ANOVA and the Newman-Keuls test. The p values <0.05 were considered significant.